Glycyrrhetinic acid is a natural pentacyclic triterpenoid compound extracted from the root and rhizome of licorice. It is the main active metabolite of glycyrrhizin in the human body, with strong biological activity and a wide range of applications in pharmaceuticals, cosmetics, and food industries.

In the pharmaceutical field, glycyrrhetinic acid has long been valued for its potent anti-inflammatory, anti-allergic, and hepatoprotective effects. Its anti-inflammatory mechanism lies in inhibiting the release of inflammatory mediators, which can effectively alleviate the symptoms of various inflammatory diseases. It is often used in the preparation of drugs for treating peptic ulcers, bronchitis, and skin inflammation. In terms of liver protection, it can enhance the detoxification function of liver cells, reduce liver damage caused by toxins or drugs, and assist in the adjuvant treatment of chronic hepatitis. Additionally, it exhibits mild antibacterial and antiviral properties, showing potential in inhibiting the growth of certain pathogenic microorganisms.

In the cosmetic industry, glycyrrhetinic acid is a popular ingredient in skincare products targeting sensitive, irritated, or acne-prone skin. First, its anti-inflammatory and soothing properties can quickly alleviate skin redness, itching, and burning sensations caused by external stimuli such as UV exposure, harsh skincare ingredients, or environmental pollutants. It is particularly suitable for post-sun repair products and skincare formulations for sensitive skin. Second, it has a mild skin-brightening effect: it can inhibit the activity of tyrosinase to a certain extent, reduce melanin synthesis, and fade post-inflammatory hyperpigmentation left by acne or sunburn, helping to even out skin tone. Moreover, it can enhance the skin barrier function by promoting the synthesis of intercellular lipids, improving the skin’s moisture-locking ability and resistance to external irritants.

In the food industry, glycyrrhetinic acid is used as a natural sweetener and flavor enhancer. It has a sweetness that is dozens of times higher than sucrose, with a pure and lasting taste, and is often added to beverages, candies, and baked goods as a low-calorie sweetening alternative.

Glycyrrhetinic acid is characterized by high safety and good compatibility with other active ingredients such as niacinamide, hyaluronic acid, and phytosphingosine. It is widely incorporated into various products, becoming a versatile natural ingredient across multiple industries.