The compound has a melting point of 44–47℃. When heated to 100℃, it loses its crystal water and turns into anhydrous piperazine. It is a weak base and can react with acids to form corresponding salts, such as piperazine citrate and piperazine phosphate, which are widely used in pharmaceutical formulations.

Core Applications

1. Pharmaceutical IndustryThis is the primary application field of piperazine hexahydrate. It serves as a key intermediate for synthesizing anthelmintic drugs (anti-parasitic medications). The salts derived from it are effective in treating infections caused by roundworms and pinworms in humans and livestock. These drugs work by paralyzing the parasites, making them easier to expel from the body without causing harm to the host.
2. Chemical SynthesisIt acts as a precursor in the production of various organic chemicals. For example, it is used to synthesize corrosion inhibitors, surfactants, and cross-linking agents for polymers. Its cyclic diamine structure enables it to participate in condensation and polymerization reactions, making it valuable for manufacturing resins and functional materials.
3. Agricultural SectorPiperazine hexahydrate and its derivatives are used to develop pesticides and animal feed additives. They can improve the disease resistance of livestock and poultry and help control intestinal parasites in breeding animals, thus promoting the healthy growth of the breeding population.
4. Laboratory ResearchIt is a common reagent in chemical laboratories, often used as a weak base catalyst or a ligand for coordinating with metal ions in coordination chemistry experiments.