p-Fluoronitrobenzene

Product Introduction

Product Namep-FluoronitrobenzeneCAS350-46-9Quality Standard StandardProduct Grad

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Update Time:2025-12
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Product Name

p-Fluoronitrobenzene

CAS

350-46-9

Quality Standard 

Standard

Product Grade

Product Grade

Place of Origin

China

Dangerous Goods 

No
p-Fluoronitrobenzene, also named 4-fluoronitrobenzene, is an important fluorine-containing aromatic organic compound with the molecular structure consisting of a benzene ring substituted by a fluoro group (-F) and a nitro group (-NO₂) at the para position. It typically appears as a pale yellow to light brown oily liquid at room temperature, with a characteristic aromatic odor.
It is slightly soluble in water but miscible with most organic solvents such as ethanol, ether, and benzene. With stable chemical properties under normal conditions, it exhibits good reactivity due to the electron-withdrawing nitro group and the electronegative fluoro group on the benzene ring, and can undergo nucleophilic substitution, reduction, and other reactions. Its boiling point is around 205°C, and it has a flash point of approximately 89°C, belonging to combustible organic substances.

Core Applications

  1. Pharmaceutical Manufacturingp-Fluoronitrobenzene is a key intermediate in the synthesis of fluorine-containing pharmaceuticals. Fluorine-containing drugs are widely used in clinical practice because of their high bioactivity, strong targeting ability, and long metabolic half-life. This compound is mainly used to produce anti-cancer drugs, anti-inflammatory drugs, and central nervous system drugs. For example, it can be used as a starting material to synthesize fluorine-containing aromatic amine derivatives, which are important components of some targeted anti-tumor drugs.
  2. Agrochemical ProductionIt serves as an essential precursor for the synthesis of high-efficiency agrochemicals, including fluorine-containing herbicides, insecticides, and fungicides. The introduction of fluorine atoms into pesticide molecules can significantly improve the pesticide's efficacy, selectivity, and photostability, while reducing its toxicity to non-target organisms. Pesticides synthesized from p-fluoronitrobenzene are widely applied in agricultural production for pest and weed control.
  3. Fine Chemicals SynthesisIt is used to produce fluorine-containing aromatic intermediates, which are further processed into specialty dyes, pigments, and functional materials. For instance, it can be used to synthesize fluorine-containing azo dyes with excellent color fastness and light resistance, suitable for dyeing high-grade textiles and coatings. In addition, it can be used to prepare fluorine-containing polymer additives to enhance the heat resistance and corrosion resistance of polymer materials.
  4. Laboratory ResearchAs a common fluorine-containing aromatic reagent, p-fluoronitrobenzene is widely used in organic chemistry research, especially in the study of reaction mechanisms of nucleophilic aromatic substitution and the synthesis of novel fluorine-containing organic molecules. It provides an important synthetic platform for the development of new materials and fine chemicals.